Effect of zinc on the treatment of Plasmodium falciparum malaria in children: a randomized controlled

Bad@nmd: Zjnc silppkmcautim in young childrca hu bcm children. and dx pogrmivc i m u x in dx rrrinra ddx prrruriated witb ductions in dx incidmu and k t y of dims i t e lo m t i d a r i a l dtugr (3L a orc dcsper. rhul diww respinlory infacionr and nularia. Objaih: The ob@w was to 4 u & c the pmcMid rok of zinc as an d j u n n in the uumcm of rute. unampf iavd fakip.rum malaria; a multiccnar. double-blind. randomized placeboconmlkd d i n i d ma was un&ukm. ~ : C h i l d r n f n = 1 0 8 1 ) l g e d 6 m , l o 5 y . w r r c e d k d u sircs in Ecmda. G h . n r T d U g u d r and Zambia Childrm w i t h f c v c r a n d ~ a M O m o d f a m s d F % z m e d m ~ ~ in a thick Mood smear m i d chloroguine and were RDdomly usigacd to r u c k zinc (20 mg/d f a infants. 40 mdd f a older children) a plrebo f a 4 d. ~ T b C T r w a s ~ ~ ) e K e c l o f ~ o n d x m c d i m t i m c m r e d o c atcly aecded. ~ ~ 5 y d d i n m J r i w d c l a i E r m r c r m t d p a r m eaagy rmlauuition. as well as d e t i i M a ia m i a a ~ l r including zinc 14). Zinc d e t i ~ i e ~ c y in bumus l trdr lo gmWb m u d r c i o n . t h y m i c ~ y . l y m p b o p c u r ~ T I . d B ~ pboc).tc hiaclion. i m p r e d chemotrtic activity of 1% uwf 8 reduction in thymulin xtivity. iacrfcra-7 and th number of C M (helper) Iympbowa 15). TLcv ahuations in dx ccllulu md b1 hmdaw m8y i bml ~vwcplibilily lo R j a k i p a ~ 15.6). Zinc +kmcmIaLkm d children in dcvcloping cnumRics bP msulud 11, i ~ v of delayed cv-s hwasclr ibr ih(71 ud M i iB CCM tion of f m r (zinc pwp: 24.2 h: plrcbo goup: 24.0 b: P = 0.37). lympbocrcs 18). ~ & q p k m a I & Im bca kn mhm a 275% rrduction in ourritcmia from baseline in dx t i i 72 b in dx inc idm. of d i h and mmmoaia 19) Id lo bc * 73.4% of the zinc group a d in 77.6% of the pl8cebo group ( P = 0.1 I). and m dgnifiMt change in bermgabin -1~ tion f i n ; ibe 3 4 priod of b o i l l i i u t i o a lad dx 4 wk d follosr-up.&npl&zincam&mkmswcmlowin.~chikcn at baseline (zinc ormu: 8.54 * 3.93 emdn. ulvebo mow: